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Myosin heads attach to begin contraction Step 5 Calcium is removed and the binding sites on actin become blocked again by tropomyosin Step 6 Muscle.

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The process of excitationcontraction EC coupling links the electric excitation of the surface membrane action potential to contraction Since the initial measurements in cardiac muscle12 an enormous amount of work has shown the underlying changes of cytoplasmic calcium concentration Ca2i.

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Linking the electrical signal to the contraction is excitation-contraction coupling. Excitation-Contraction Coupling in Heart Muscle is the mechanism by which AP causes myofibrils of cardiac muscle to contract When AP.

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